top of page
Windows 7 ultimate collection of wallpapers (60).jpg

Impact of Microplastic Pollution on Human Health

Pamil Tayal, Shantanu Mandal, Pawani Pandey, Nipun Kumar Verma

2023/09/02

DOI: 10.5281/zenodo.8311591

ABSTRACT

Besides visible plastic pollution, there is also a microplastic threat. Microplastics are ultrasmall plastic items, smaller than 5 mm in size. The presence of microplastics in aquatic ecosystems is increasing at an exponential rate posing a direct or indirect threat to all biodiversity on the planet This paper highlights the Indian scenario of microplastic pollution in comparison with developed regions of the globe while primarily focusing on impacts on human health. Microplastic particles are not metabolised by living organisms and thus they keep bioaccumulating. These tiny plastics also sorb a wide plethora of chemical substances that may have severe effects on life forms. Pathogenic bacteria may also adhere to microplastics affecting health. Exposure to microplastics has become impossible to avoid as these tiny plastics can enter through food, cosmetics and even via air. Besides bioaccumulating microplastics have been proven to interfere with cellular processes and normal physiological functioning of the human body. Very few papers have been published to date highlighting this issue, more research needs to be done on sources, distribution patterns and effects of microplastics on the ecosystem and humans.

AUTHOR AFFILIATIONS

Department of Botany, Sri Venkateswara College, University of Delhi, New Delhi -110021

29111_edited.jpg

CITATION

Tayal P, Mandal S, Pandey P and Verma NK (2023) Impact of Microplastic Pollution on Human Health. Environ Sci Arch 2(2): 195-204.

REFERENCES

1. ACEA - European Automobile Manufacturers' Association (2022) Report - Vehicles in use, Europe 2022. [online] Available at: https://www.acea.auto/publication/report-vehicles-in-use-europe-2022/

2. Andrady A, Pegram and Searle (1996) Wavelength sensitivity of enhanced photodegradable polyethylenes, ECO, and LDPE/MX. Journal of Applied Polymer Science, 62(9): 1457-1463.

3. Barnes, Galgani, Thompson R and Barlaz M (2009) . Accumulation and fragmentation of plastic debris in global environments. Philosophical Transactions of the Royal Society B: Biological Sciences, 364(1526): 1985-1998.

4. Berntsen P, Park C, Rothen-Rutishauser B, et al. (2010) Biomechanical effects of environmental and engineered particles on human airway smooth muscle cells. Journal of The Royal Society Interface, 7(suppl_3)

5. Borm P, Höhr D, Steinfartz Y, Zeitträger I and Albrecet C (2000) Chronic Inflammation and Tumor Formation in Rats After Intratracheal Instillation of High Doses of Coal Dusts, Titanium Dioxides, and Quartz. Inhalation Toxicology, 12(sup3):225-231.

6. Boucher J and Friot D (2017) Primary Microplastics in the Oceans: A Global Evaluation of Sources. IUCN, Gland, 43 p. https://doi.org/10.2305/IUCN.CH.2017.01.en

7. Brown D, Donaldson K and Stone V (2004) Effects of PM10 in human peripheral blood monocytes and J774 macrophages. Respiratory Research, 5(1) https://doi.org/10.1186/1465-9921-5-29

8. Browne MA, Dissanayake A, Galloway TS, Lowe DM and Thompson RC (2008) Ingested microscopic plastic translocates to the circulatory system of the mussel, Mytilus edulis (L.) Environmental Science and Technology 42(13): 5026-5031 https://doi.org/10.1021/es800249a

9. Calma J (2020) The US is one of the world’s biggest sources of plastic pollution. [online] The Verge. Available at: https://www.theverge.com/2020/10/30/21542109/plastic-waste-united-states-ocean-pollution-study

10. Cera A, Cesarini G and Scalici M (2020) Microplastics in Freshwater: What Is the News from the World? Diversity, 12(7), p.276. https://doi.org/10.3390/d12070276

11. Cole M, Lindeque P, Halsband C and Galloway T (2011) Microplastics as contaminants in the marine environment: A review. Marine Pollution Bulletin, 62(12):2588-2597.

12. Danforth E (2000) Failure of adipocyte differentiation causes type II diabetes mellitus? Nature Genetics, 26(1):13. https://doi.org/10.1038/79111

13. Egusquiza R and Blumberg B (2020) Environmental Obesogens and Their Impact on Susceptibility to Obesity: New Mechanisms and Chemicals. Endocrinology 161(3) https://doi.org/10.1210/endocr/bqaa024

14. Evers J, Emdash (2022) Great Pacific Garbage Patch. [online] Education.nationalgeographic.org. Available at: https://education.nationalgeographic.org/resource/great-pacific-garbage-patch

15. Forschungsverbund Berlin (2019) Microorganisms on microplastics. Science Daily. www.sciencedaily.com/releases/2019/06/190605121655.htm

16. Fröhlich E (2012) The role of surface charge in cellular uptake and cytotoxicity of medical nanoparticles. International Journal of Nanomedicine, 5577.

17. Fröhlich E, Samberger C, Kueznik T, Absenger M, Roblegg E, Zimmer A and Pieber T (2009) Cytotoxicity of nanoparticles independent from oxidative stress. The Journal of Toxicological Sciences, 34(4):363-375.

18. Gasperi J, Wright S, Dris R, et al. (2018) Microplastics in air: Are we breathing it in? Current Opinion in Environmental Science and; Health, 1, pp.1-5.

19. GESAMP (2015) Sources, fate and effects of MPs in the marine environment: a global assessment (Kershaw, P. J., ed.) (IMO/FAO/UNESCO-IOC/UNIDO/WMO/IAEA/UN/UNEP/UNDP Joint Group of Experts on the Scientific Aspects of Marine Environmental Protection) Reproductive Studies, GESAMP No. 90: 96.

20. Greim H, Borm P, Schins R, Donaldson K, Driscoll K, Hartwig A, Kuempel E, Oberdörster G and Speit G (2001) Toxicity of fibers and particles—report of the workshop held in Munich, Germany, 26–27 OCTOBER 2000. Inhalation Toxicology, 13(9):737-754.

21. Leslie HA (2014) Review of Microplastics in Cosmetics - Scientific background on a potential source of plastic particulate marine litter to support decision-making. IVM Institute for Environmental Studies.

22. Hale R, Seeley M, La Guardia M, Mai L and Zeng E (2020) A Global Perspective on Microplastics. Journal of Geophysical Research: Oceans, 125(1) https://doi.org/10.1029/2018JC014719

23. Herrera A, Asensio M, Martínez I, Santana A, Packard T and Gómez M (2018) Microplastic and tar pollution on three Canary Islands beaches: An annual study. Marine Pollution Bulletin, 129(2):494-502.

24. Höher N, Köhler A, Strand J and Broeg K (2012) Effects of various pollutant mixtures on immune responses of the blue mussel (Mytilus edulis) collected at a salinity gradient in Danish coastal waters. Marine Environmental Research 75:35-44.

25. Holmes L, Turner A and Thompson R (2012) Adsorption of trace metals to plastic resin pellets in the marine environment. Environmental Pollution 160:42-48.

26. Horton A, Svendsen C, Williams R, Spurgeon D and Lahive E (2017) Large microplastic particles in sediments of tributaries of the River Thames, UK – Abundance, sources and methods for effective quantification. Marine Pollution Bulletin, 114(1):218-226. https://doi.org/10.1016/j.marpolbul.2016.09.004

27. Hussain N, Jaitley V and Florence AT (2001) Recent advances in the understanding of uptake of microparticulates across the gastrointestinal lymphatics. Advanced Drug Delivery Reviews 50(1-2):107-142.

28. IUCN (2021) Marine plastic pollution. [online] Available at: https://www.iucn.org/resources/marine-plastic-pollution

29. Jin H, Ma T, Sha X, et al. (2021) Polystyrene microplastics induced male reproductive toxicity in mice. Journal of Hazardous Materials, 401:123430. https://doi.org/10.1016/j.jhazmat.2020.123430

30. Jin Y, Lu L, Tu W, Luo T and Fu Z (2019) Impacts of polystyrene microplastic on the gut barrier, microbiota and metabolism of mice. Science of The Total Environment 649: 308-317. https://doi.org/10.1016/j.scitotenv.2018.08.353

31. Kannan K and Vimalkumar K (2021) A Review of Human Exposure to Microplastics and Insights Into Microplastics as Obesogens. Frontiers in Endocrinology 12. https://doi.org/10.3389/fendo.2021.724989

32. Kelly B, Gobas F and McLachlan M (2004) Intestinal absorption and biomagnification of organic contaminants in fish, wildlife, and humans. Environmental Toxicology and Chemistry 23(10): 2324. https://doi.org/10.1897/03-545

33. Kettner M, Oberbeckmann S, Labrenz M and Grossart H (2019) The Eukaryotic Life on Microplastics in Brackish Ecosystems. Frontiers in Microbiology 10. https://doi.org/10.3389/fmicb.2019.00538

34. Kosuth M, Mason S and Wattenberg E (2018) Anthropogenic contamination of tap water, beer, and sea salt. PLOS ONE 13(4): e0194970. https://doi.org/10.1371/journal.pone.0194970

35. Kutralam-Muniasamy G, Pérez-Guevara F, Elizalde-Martínez I and Shruti V (2020) Branded milks – Are they immune from microplastics contamination? Science of The Total Environment 714: 136823. https://doi.org/10.1016/j.scitotenv.2020.136823

36. Li B, Ding Y, Cheng X, et al. (2020) Polyethylene microplastics affect the distribution of gut microbiota and inflammation development in mice. Chemosphere 244: 125492. https://doi.org/10.1016/j.chemosphere.2019.125492

37. Lithner D, Damberg J, Dave G and Larsson Å (2009) Leachates from plastic consumer products – Screening for toxicity with Daphnia magna. Chemosphere 74(9): 1195-1200. 10.1016/j.chemosphere.2008.11.022

38. Mahesh P, Mukherjee M (2018) Microplastics: The most widespread and persistent hazards of plastic. Toxics Link. Factsheet number 56. http://toxicslink.org/Publication/factsheet-56-on-microplastics.

39. Martinez E, Maamaatuaiahutapu K and Taillandier V (2009) Floating marine debris surface drift: Convergence and accumulation toward the South Pacific subtropical gyre. Marine Pollution Bulletin 58(9): 1347-1355. https://doi.org/10.1016/j.marpolbul.2009.04.022

40. Moore M (2006) Do nanoparticles present ecotoxicological risks for the health of the aquatic environment? Environment International 32(8): 967-976. https://doi.org/10.1016/j.envint.2006.06.014

41. NEA (2014) Sources of microplastics to the marine environment. Norwegian Environment Agency. https://www.miljodirektoratetno/publikasjoner/2015/februar/sources-of-microplastic-pollution-to-the-marine-environment/

42. Neill P (2020) Maldives has highest levels of microplastics in the world. [online] Environment Journal. Available at: https://environmentjournal.online/articles/maldives-has-highest-levels-of-microplastics-in-the-world/

43. Obbard R, Sadri S, Wong Y, Khitun A, Baker I and Thompson R (2014) Global warming releases microplastic legacy frozen in Arctic Sea ice. Earth's Future 2(6): 315-320. https://doi:10.1002/2014ef000240

44. Oceanservice.noaa.gov. (2021) What are microplastics? [online] Available at: https://oceanservice.noaa.gov/facts/microplastics.html

45. Park E, Han J, Park E, et al. (2020) Repeated-oral dose toxicity of polyethylene microplastics and the possible implications on reproduction and development of the next generation. Toxicology Letters 324: 75-85. https://doi.org/10.1016/j.toxlet2020.01.008

46. Rank J, Lehtonen K, Strand J and Laursen M (2007) DNA damage, acetylcholinesterase activity and lysosomal stability in native and transplanted mussels (Mytilus edulis) in areas close to coastal chemical dumping sites in Denmark. Aquatic Toxicology 84(1): 50-61.

47. Rochman C, Hoh E, Kurobe T and Teh S (2013) Ingested plastic transfers hazardous chemicals to fish and induces hepatic stress. Scientific Reports 3(1). https://doi.org/10.1038/srep03263

48. Ryan P, Connell A and Gardner B (1988) Plastic ingestion and PCBs in seabirds: Is there a relationship? Marine Pollution Bulletin 19(4): 174-176. https://doi.org/10.1016/0025-326X(88)90674-1

49. Shahul Hamid F, Bhatti M, et al. (2018) Worldwide distribution and abundance of microplastic: How dire is the situation? Waste Management & Research: The Journal for a Sustainable Circular Economy 36(10): 873-897.

50. Shin J and Abraham S (2001) Caveolae-Not Just Craters in the Cellular Landscape. Science 293(5534): 1447-1448. https://doi.org/10.1126/science.1061079

51. Smith M, Love D, Rochman C and Neff R (2018) Microplastics in Seafood and the Implications for Human Health. Current Environmental Health Reports 5(3): 375-386. https://doi.org/10.1007/s40572-018-0206-z

52. Snoussi M, Noumi E, Usai D, Sechi L, Zanetti S and Bakhrouf A (2008) Distribution of some virulence related-properties of Vibrio alginolyticus strains isolated from Mediterranean seawater (Bay of Khenis, Tunisia): investigation of eight Vibrio cholerae virulence genes. World Journal of Microbiology and Biotechnology 24(10): 2133-2141.

53. Sussarellu R, Suquet M, Thomas Y, et al. (2016) Oyster reproduction is affected by exposure to polystyrene microplastics. Proceedings of the National Academy of Sciences 113(9): 2430-2435. https://doi.org/10.1073/pnas.1519019113

54. Teuten E, Saquing J, Knappe D, et al. (2009) Transport and release of chemicals from plastics to the environment and to wildlife. Philosophical Transactions of the Royal Society B: Biological Sciences 364(1526): 2027-2045.

55. Thompson R, Moore C, vom Saal F and Swan S (2009) Plastics, the environment and human health: current consensus and future trends. Philosophical Transactions of the Royal Society B: Biological Sciences 364(1526): 2153-2166.

56. Tyree C and Morrison D (2018) Plus, Plastic Text — Orb Media. [online] Orb Media. Available at: https://orbmedia.org/plus-plastic-text

57. Unep.org. n.d. Visual Feature | Beat Plastic Pollution. [online] Available at: https://www.unep.org/interactives/beat-plastic-pollution/

58. Uurasjärvi E, Hartikainen S, Setälä O, Lehtiniemi M and Koistinen A (2020) Microplastic concentrations, size distribution, and polymer types in the surface waters of a northern European lake. Water Environment Research 92(1): 149-156. https://doi.org/10.1002/wer.1229

59. van der Goot F and Gruenberg J (2002) Oiling the wheels of the endocytic pathway. Trends in Cell Biology 12(7): 296-299. https://doi.org/10.1016/S0962-8924(02)02307-3

60. Veneman W, Spaink H, Brun N, Bosker T and Vijver M (2017) Pathway analysis of systemic transcriptome responses to injected polystyrene particles in zebrafish larvae. Aquatic Toxicology 190: 112-120. https://doi.org/10.1016/j.aquatox.2017.06.014

61. von Moos N, Burkhardt-Holm P and Köhler A (2012) Uptake and Effects of Microplastics on Cells and Tissue of the Blue Mussel Mytilus edulis L. after an Experimental Exposure. Environmental Science &amp Technology 46(20): 11327-11335. https://doi.org/10.1021/es302332w

62. Wagner M, Scherer C, Alvarez-Muñoz D, et al. (2014) Microplastics in freshwater ecosystems: what we know and what we need to know. Environmental Sciences Europe 26(1). https://doi.org/10.1186/s12302-014-0012-7

63. Warheit D, Hart G, Hesterberg T, et al. (2001) Potential Pulmonary Effects of Man-Made Organic Fiber (MMOF) Dusts. Critical Reviews in Toxicology 31(6): 697-736.

64. Wick P, Malek A, Manser P, et al. (2010) Barrier Capacity of Human Placenta for Nanosized Materials. Environmental Health Perspectives 118(3): 432-436. https://doi.org/10.1289/ehp.0901200

65. Woodford C (2022) Plastics. Explain that Stuff website. https://www.explainthatstuff.com/plastics.html

66. World Population Review (2022) Plastic Pollution by Country (2022) World Population Review website. https://worldpopulationreview.com/country-rankings/plastic-pollution-by-country

67. Yang D, Shi H, Li L, Li J, Jabeen K and Kolandhasamy P (2015) Microplastic Pollution in Table Salts from China. Environmental Science & Technology 49(22): 13622-13627. https://doi.org/10.1021/acs.est.5b03163

68. Zarfl C and Matthies M (2010) Are marine plastic particles transport vectors for organic pollutants to the Arctic? Marine Pollution Bulletin 60(10): 1810-1814.

69. Zettler E, Mincer T and Amaral-Zettler L (2013) Life in the “Plastisphere”: Microbial Communities on Plastic Marine Debris. Environmental Science & Technology 47(13): 7137-7146. https://doi.org/10.1021/es401288x

by.png

License: Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution, and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third-party material in this article are included in the article’s Creative Commons license unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. Visit for more details http://creativecommons.org/licenses/by/4.0/.

bottom of page