ABSTRACT
The toxicological interaction of fungicide (carbendazim: CBZ) and insecticide (imidacloprid: IMI) was evaluated using a mouse model system. Mice received IMI-L & IMI-H (45.5 & 90.0 mg/kg feed, respectively), CBZ-L & CBZ-H (1.4 and 2.8g/kg feed, respectively) and in combination (IMI-L+CBZ-L) through the feed. Various toxicological endpoints were evaluated, including feed and water consumption, biochemical parameters, oxidative stress, antioxidants, and neurotoxicity, and the interactive index was calculated. A decrease in feed and water consumption and body weight loss was noticed in CBZ and IMI-treated groups and in combination. A significant change in cytotoxicity biochemical indicators was noticed in IMI and CBZ alone-treated groups as compared to control and combined (IMI-L+CBZ-L) treated groups. Non-significant changes (p≥0.05) in oxidative stress biomarkers and antioxidants were observed in the IMI-L+CBZ-L group compared with the respective alone-treated groups. Plasma and brain, AChE activity was significantly (p≤0.05) altered in IMI-L+CBZ-L group when compared with IMI-L and CBZ-L alone groups. Motor activity (FLA and SLA) significantly (p≤0.05) decreased in IMI and CBZ-treated groups as compared to the combined group. Response to pain significantly (p≤0.05) increased in IMI and CBZ alone groups when compared with the control and IMI-L+CBZ-L groups. The interactive index calculated for the parameters under investigation indicates the majority of antagonism. The present study suggests that IMI and CBZ exposure via the dietary medium has a dose-dependent toxic effect, but the existence of both in a dietary medium does not lead to additivity or synergism.
AUTHOR AFFILIATIONS
1 Department of Veterinary Pharmacology and Toxicology, Guru Angad Dev Veterinary and Animal Sciences University, Ludhiana, Punjab-141004, India
2 Department of Veterinary Physiology and Biochemistry, Guru Angad Dev Veterinary and Animal Sciences University, Ludhiana, Punjab-141004, India
3 Department of Veterinary Pathology, Guru Angad Dev Veterinary and Animal Sciences University, Ludhiana, Punjab-141004, India
CITATION
Beg S, Lonare MK, Sharma M, Deshmukh S and Dumka VK (2025) Effect of Dietary Exposure to Carbendazim and Imidaclorpid on Biochemicals, Oxidative Stress and Neurotoxicity in Albino Mice. Environmental Science Archives 4(2): 782-800.
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